Dr. Page Pennell
- Sun Sep 22 11:20 AM - 12:00 PM Imperial DAED TDM in Women of Child Bearing Potential and in Pregnancy
Page B. Pennell, MD is Associate Professor of Neurology at Harvard Medical School and Director of Research for the Division of Epilepsy, EEG, and Sleep in the Department of Neurology at Brigham and Women’s Hospital (BWH), with a secondary appointment in the Division of Women’s Health. She is a clinician investigator with a focus on sex-specific outcomes in epilepsy. Dr. Pennell’s current clinical studies focus on the effects of hormones on seizure provocation, pharmacokinetic changes of AEDs with exogenous hormones or differing reproductive phases, and maternal and fetal outcomes during pregnancy in women with epilepsy. Collaborative, multi-center studies have included funding from industry, non-profit foundations and NIH; these studies have included treatment of women with epilepsy with hormone therapeutics, study of the effects of epilepsy and antiepileptic drugs (AEDs) on sex steroid hormones and the functional consequences, and study of women with epilepsy during pregnancy. This has culminated in the recent NIH-funding of a multi-center clinical trial across 20 sites, Maternal Outcomes and Neurodevelopmental Effects of AEDs (MONEAD), by NINDS and NICHD, https://web.emmes.com/study/monead/index.htm. Dr. Pennell serves as multi-Principal Investigator of this project along with Dr. Kimford Meador. Involvement in other current studies include a three-site study of fertility, seizure frequency and relationship to hormonal status, Women with Epilepsy: Pregnancy Outcomes and Deliveries (WEPOD), and the study Pharmacogenics and Pharmacokinetics in Early Pregnancy (P-PEP). Dr. Pennell is also Principal Investigator of a study examining effects of reproductive hormones and neuroactive steroids on seizure control during pregnancy, funded by NINDS.
Dr. Pennell serves on the Board of Directors for the American Epilepsy Society, the Professional Advisory Board of the Epilepsy Foundation, and as Director of the Epilepsy course at the annual meeting for the American Academy of Neurology. She previously directed the AAN course Neurologic Complications in Pregnant Women. She has over 80 original and peer-reviewed articles in the field, with a clear focus on sex-specific and neuroendocrine considerations in epilepsy. She has contributed over 10 book chapters and been guest editor of publications focusing on neurology illnesses and pregnancy. She has served on the editorial board of Epilepsia and Epilepsy Currents.