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PK/PD Modeling of AEDs and Its Application to TDM

PK/PD Modeling of AEDs and Its Application to TDM

Sun Sep 22 2:50 PM - 3:30 PM

  • Imperial D

This will include the use of software to model patient outcome based on TDM data. Also, the use of population data from clinical trials and population data from TDM services to inform on AED PK characteristics and potential PK interactions.


Objectives:

At the end of this session the participants will be able to:

  • Appreciate the potential of the application of population model-based approached to to AED therapeutics.
  • Appreciate the importance of informative experimental design in PK studies.
  • Describe model based Bayesian adaptive control as an attractive strategy for AED dose individualization.

Description:

This presentation will review the application of population PK/PD model-based dose optimization of AE drugs. It will review the use of clinical software to predict drug exposure and drug-drug interactions based on sparse TDM data. Examples of how modeling and simulation can help in the design of informative studies and individualized treatment will be discussed.

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Pre-Congress Symposium: 100 Years of Antiepileptic Drugs: The Role of TDM in Optimizing Patient Care