This will cover the special need of AED TDM in this population which is associated with significant pharmacokinetic variability and constantly changing metabolic capacity.
At the end of this session the participants will be able to:
- Demonstrate the clinical importance of therapeutic drug monitoring in young people with epilepsy.
- Indicate the value of tracking blood levels to reveal unsuspected drug interactions.
- Provide examples of the clinical importance of therapeutic drug monitoring in managing and preventing drug toxicity.
- Illustrate how therapeutic drug monitoring can be used to guide the management of both pharmacokinetic and pharmacodynamic drug interactions in young people with epilepsy.
Compliance (adherence, concordance) with medication depends not only on efficacy but also on tolerability. Therapeutic drug monitoring of antiepileptic medication children and teenagers can be of benefit with regard to both efficacy and tolerability, especially at a time when not only metabolic parameters are changing but the manifestations of the epilepsy are also liable to undergo major change. In this session, specific clinical examples will be given of how therapeutic monitoring of antiepileptic medication has been of value in practice and how therapeutic drug monitoring research has informed the clinician. Determining blood levels of antiepileptic medication can be of major value when managing certain particular antiepileptic drugs. A case is made for specifically-targeted therapeutic drug monitoring, where it is most likely to be of clinical benefit.