At the end of this session the participants will be able to:
- To understand that AEDs can transfer from blood into alternative biological matrices.
- To appreciate the potential for TDM of AEDs in various biological matrices.
- To learn about practical issues associated with TDM of AEDs in the alternative matrices.
The measurement of antiepileptic drugs (AEDs) in plasma/serum has proved to be a valuable adjunct to the management of individual patients with epilepsy for the past 40 years or more. This presentation will review and discuss the value of undertaking AED measurements in some alternative biological matrices e.g. saliva, blood spots and hair, compared with serum/plasma. The added value of each biomatix will be compared and disadvantages reviewed together with some practical approaches to the use of alternative biological specimens for AED dose individualisation.